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Verospiron PLUS
Frusemide 20 mg + Spironolactone 50 mg Tablet is used for the treatment of Hypertension, Congestive heart failure, Oedema, Ascites
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✅ Description:
Indications:
- Essential hypertension
- Chronic congestive heart failure
- Hepatic cirrhosis, with fluid accumulation in the abdominal cavity (ascites)
- Swelling due to excess fluid retention (edema)
- Hyperaldosteronism
- Resistant edema associated with secondary hyperaldosteronism
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Use in Special Populations:
- Not suitable for use in children.
- Spironolactone and Furosemide may be excreted more slowly in the elderly.
✔️ Overdose Effects:
- Symptoms may include drowsiness, mental confusion, dizziness, diarrhea, and vomiting.
- Treatment should focus on fluid replacement and correction of electrolyte imbalance.
✔️ Side Effects:
- Headache, drowsiness, gastrointestinal distress.
- Ataxia, mental confusion, skin rashes.
- Gynecomastia, breast enlargement, and other endocrine disorders.
- Transient increase in blood-urea-nitrogen concentrations, mild acidosis.
- Hyponatremia, hyperkalemia.
- Excessive diuresis may lead to dehydration and circulatory collapse.
✔️ Therapeutic Class:
- Potassium-sparing diuretics
- Potassium-sparing diuretics & Aldosterone antagonists
✔️ Pharmacology:
- Furosemide inhibits the Na+/K+/2Cl- co-transporter in the ascending Loop of Henle, increasing the excretion of sodium and water.
- Spironolactone inhibits sodium reabsorption at the distal tubule by antagonizing aldosterone, reducing excess potassium loss induced by Furosemide.
✔️ Dosage & Administration:
- Furosemide 20 mg and Spironolactone 50 mg: 1 to 4 tablets daily (20 to 80 mg Furosemide and 50 to 200 mg Spironolactone) according to the patient’s response.
- Furosemide 40 mg and Spironolactone 50 mg: For stabilized patients requiring higher dosage, 1 to 2 tablets daily (40 to 80 mg of Furosemide and 50 to 100 mg of Spironolactone).
✔️ Interactions:
- Increased risk of hyperkalemia when taken with ACE inhibitors or potassium salts.
- Spironolactone may increase levels of cardiac glycosides, leading to digitalis toxicity.
- Corticosteroids may cause hypokalemia when used with Spironolactone.
- Furosemide's effects may be reduced when used with indomethacin and other NSAIDs.
- Simultaneous administration of sucralfate and Furosemide may reduce their effects.
✔️ Contraindications:
- Anuria, acute renal insufficiency, severe impairment of renal function (creatinine clearance <30 ml/min), hyperkalemia, Addison's disease.
- Hypersensitivity to Spironolactone, Furosemide, or sulphonamides.
✔️ Pregnancy & Lactation:
- Spironolactone and Furosemide may cross the placental barrier.
- Furosemide may cause fetal abnormalities.
- Use in pregnancy and lactation should be carefully weighed against potential risks.
✔️ Precautions & Warnings:
- Caution in patients prone to electrolyte deficiency, diabetes, enlarged prostate, hypotension, and hypovolemia.
✔️ Storage Conditions
- Keep below 30°C, away from light & moisture.
- Keep out of the reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
